Recovery of natural killer cell cytotoxicity in a p.A91V perforin homozygous patient following severe haemophagocytic lymphohistiocytosis

HS Jang; TWH Flinsenberg; P Lacaze; KYT Thia; T Noori; SL Fernando; I Kerridge; M Riaz; JJ McNeil; PA Blombery; JA Trapani; I Voskoboinik

Journal article

Recovery of natural killer cell cytotoxicity in a p.A91V perforin homozygous patient following severe haemophagocytic lymphohistiocytosis

HS Jang, TWH Flinsenberg, P Lacaze, KYT Thia, T Noori, SL Fernando, I Kerridge, M Riaz, JJ McNeil, PA Blombery, JA Trapani, I Voskoboinik

British Journal of Haematology | WILEY | Published : 2020

DOI: 10.1111/bjh.16660

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University of Melbourne Researchers

Joseph Trapani Author

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THE BIOGENESIS OF CYTOTOXIC GRANULES

Cytotoxic lymphocytes are immune cells responsible for the killing infected or cancerous cells. How cytotoxic lymphocytes mature from a naiv..

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Funding Acknowledgements

Supported by grants (334047, 1127060, 1128587) and a fellowship (1059126) from the National Health and Medical Research Council of Australia, by Monash University and the Victorian Cancer Agency.

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Keywords

Science & Technology

Hematology

Life Sciences & Biomedicine

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Biodefense

32 Biomedical and Clinical Sciences